Modelling the anti‐herpes simplex virus activity of small cationic peptides using amino acid descriptors
Identifieur interne : 002F79 ( Main/Exploration ); précédent : 002F78; suivant : 002F80Modelling the anti‐herpes simplex virus activity of small cationic peptides using amino acid descriptors
Auteurs : H. Jenssen [Norvège] ; T. J. Gutteberg [Norvège] ; T. Lejon [Norvège]Source :
- The Journal of Peptide Research [ 1397-002X ] ; 2005-12.
Abstract
Abstract: There are a number of diseases associated with herpes simplex virus infections, and although there are available treatments, there is still a need for new therapies. Some peptides have proved to have an antiviral effect, but the high flexibility and complex mode of action makes it difficult to obtain reliable quantitative structure–activity relationships. In this article, we report on the use of theoretically derived amino acid descriptors for the modelling of peptide activity as a mean to find lead compounds based on biologically active peptides.
Url:
DOI: 10.1111/j.1747-0285.2006.00332.x
Affiliations:
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Lejon, Department of Chemistry, University of Tromsø, N‐9037 Tromsø</wicri:regionArea><wicri:noRegion>N‐9037 Tromsø</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">The Journal of Peptide Research</title><title level="j" type="alt">JOURNAL OF PEPTIDE RESEARCH</title><idno type="ISSN">1397-002X</idno><idno type="eISSN">1399-3011</idno><imprint><biblScope unit="vol">66</biblScope><biblScope unit="issue">s1</biblScope><biblScope unit="page" from="48">48</biblScope><biblScope unit="page" to="56">56</biblScope><biblScope unit="page-count">9</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2005-12">2005-12</date></imprint><idno type="ISSN">1397-002X</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1397-002X</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: There are a number of diseases associated with herpes simplex virus infections, and although there are available treatments, there is still a need for new therapies. 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